Disable Notification Center on OS X Revision as of Tuesday, 3 June 2025 at 19:29 UTC

# Disable permanently
sudo defaults write /System/Library/LaunchAgents/com.apple.notificationcenterui KeepAlive -bool false

# Enable
sudo defaults write /System/Library/LaunchAgents/com.apple.notificationcenterui KeepAlive -bool true

# Kill now
killall NotificationCenter